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KMID : 0043320010240030180
Archives of Pharmacal Research
2001 Volume.24 No. 3 p.180 ~ p.189
Syntheses of New Salicylamide Derivatives with Ewaluation of Their Antiinflammatory Analgesic and Antipyretic Activities
Famhy HH
Soliman GA
Abstract
A new series of pyridazine, pyrazoles, pyrazolidine-3,5-dione, Semicarbazide, thiosemicarbazides, hydantoin, thiohydantoins, 1,2,4- 1,B,4-triazoles, S-triazolo[3,4-b]-1,3,,4-thi adiazoles incororated indirectly into salicylamide moiety at position 2 were synthesized. Also the synthesis of novel series of 3-salicylamido-2-hydroxypropyl-amine derivatives were prepared. Several of these compounds were screened for antiinflammatory, antipyretic and ulcerogenic activities.
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